[1]林洁,郭慈仁,陈雪燕,等.P16蛋白和Ki-67抗原在宫颈上皮内瘤变分级诊断中的价值[J].福建医药杂志,2021,43(06):16-17.
 LIN Jie,GUO Ciren,CHEN Xueyan,et al.Significance of P16 protein and Ki-67 antigen in diagnosis of cervical intraepithelial neoplasia[J].FUJIAN MEDICAL JOURNAL,2021,43(06):16-17.
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P16蛋白和Ki-67抗原在宫颈上皮内瘤变分级诊断中的价值()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
43
期数:
2021年06期
页码:
16-17
栏目:
临床研究
出版日期:
2021-12-15

文章信息/Info

Title:
Significance of P16 protein and Ki-67 antigen in diagnosis of cervical intraepithelial neoplasia
文章编号:
1002-2600(2021)06-0016-02
作者:
林洁郭慈仁1陈雪燕2林杰祥3刘彬陈桂林江信燕
福建省肿瘤医院 福建医科大学附属肿瘤医院妇科(福州 350014)
Author(s):
LIN Jie GUO Ciren CHEN Xueyan LIN Jiexiang LIU Bin CHEN Guilin JIANG Xinyan
Department of Tumor Gynaecology,Fujian Cancer Hospital,Fujian Medical University Cancer Hospital,Fuzhou,Fujian 350014,China
关键词:
P16 Ki-67 宫颈低级别上皮内瘤变 宫颈高级别上皮内瘤变 慢性宫颈炎
Keywords:
P16 Ki-67 low-grade cervical intraepithelial neoplasia high-grade cervical intraepithelial neoplasia chronic cervicitis
分类号:
R711.32; R711.7
文献标志码:
B
摘要:
目的 探讨P16蛋白和Ki-67抗原在宫颈上皮内瘤变分级诊断中的价值。方法 选择2019年1月至2021年1月我院诊治的50例慢性宫颈炎患者、80例宫颈低级别上皮内瘤变患者和80例宫颈高级别上皮内瘤变患者为研究对象,采用免疫组化法检测各组宫颈组织中P16蛋白和Ki-67抗原的表达情况,并对结果进行统计学分析。结果 P16蛋白和Ki-67抗原阳性表达率,宫颈高级别上皮内瘤变患者明显高于低级别上皮内瘤变患者(P<0.05); P16蛋白和Ki-67抗原的表达,宫颈上皮内瘤变患者均高于慢性宫颈炎患者(P<0.05)。结论 P16蛋白和Ki-67抗原可作为宫颈上皮内瘤变分层管理的重要判断指标。
Abstract:
Objective To investigate the value of P16 and Ki-67 proteins in diagnosis of cervical intraepithelial neoplasia.Methods From January 2019 to January 2021,50 patients with chronic cervicitis, 80 patients with low-grade cervical intraepithelial neoplasia and 80 patients with high-grade cervical intraepithelial neoplasia were selected as research objects.Immunohistochemical method was used to detect the expression of P16 and Ki-67 in three groups and the results were statistically analyzed.Results The positive expression rates of P16 and Ki-67 in patients with high-grade cervical intraepithelial neoplasia were significantly higher than those in patients with low-grade cervical intraepithelial neoplasia(P<0.05); the positive expression rates of P16 and Ki-67 in patients with cervical intraepithelial neoplasia were significantly higher than those in patients with chronic cervicitis(P<0.05).Conclusion P16 and Ki-67 have a good diagnostic value for cervical intraepithelial neoplasia.

参考文献/References:

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备注/Memo

备注/Memo:
1 通信作者,Email:guozhiyin505@sina.com; 2 病理科; 3 福建省立医院泌尿外科
更新日期/Last Update: 2021-12-15