[1]杨则堂,关海山,许红波,等.脐带血碱性磷酸酶在新生儿黄疸诊断中的应用价值[J].福建医药杂志,2021,43(01):92-95.
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脐带血碱性磷酸酶在新生儿黄疸诊断中的应用价值()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
43
期数:
2021年01期
页码:
92-95
栏目:
临床研究
出版日期:
2021-02-10

文章信息/Info

文章编号:
1002-2600(2021)01-0092-04
作者:
杨则堂; 关海山; 许红波; 李红; 王源
福建省厦门长庚医院儿科(厦门 460000)
关键词:
脐带血;  碱性磷酸酶;  新生儿;  高胆红素血症
分类号:
R722.17
文献标志码:
B
摘要:
目的 探讨脐带血碱性磷酸酶在预测新生儿高胆红素血症发生中的有效性及诊断价值。方法 采用我院2018年6月至2019年6月出生的216例新生儿作为研究对象,详细纪录了新生儿及其母亲的一般情况; 出生后即时测定脐静脉血碱性磷酸酶水平,并监测黄疸新生儿血清胆红素,根据血清胆红素水平进行治疗; 对各组新生儿碱性磷酸酶水平进行比较,通过受试者工作特征(ROC)曲线评价脐带血碱性磷酸酶在诊断新生儿高胆红素血症中的价值。结果 非黄疸组平均碱性磷酸酶(280.21±42.50)IU /L; 临床黄疸组碱性磷酸酶(292.25±40.25)IU/L; 血清胆红素≥12.1 mg/dL的黄疸组碱性磷酸酶为(312.60±48.64)IU/L(P<0.05)。以小时胆红素曲线进行治疗,黄疸组脐带血中碱性磷酸酶为(315.80±43.82)IU/L(P<0.05)。脐带血中碱性磷酸酶以300 IU/L作为临界值预测需要治疗的新生儿高胆红素血症的敏感度为83%,特异度为85%。结论 脐带血碱性磷酸酶水平可作为预测足月儿即将发生严重的高胆红素血症的指标。

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更新日期/Last Update: 2021-02-10