[1]林 勇 林 春 孙 芳 周 锐 杨文彦 周丽娜叶雅妹 潘 晨.乙型肝炎慢加急性肝衰竭患者血清miR-122水平与预后的相关性[J].福建医药杂志,2020,42(06):22-25.
　LIN Yong,LIN Chun,SUN Fang,et al.Correlation between serum miR-122 level and prognosis of patients with acute-on-chronic hepatitis B liver failure[J].FUJIAN MEDICAL JOURNAL,2020,42(06):22-25.
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乙型肝炎慢加急性肝衰竭患者血清miR-122水平与预后的相关性()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
42
期数:
2020年06期
页码:
22-25
栏目:
临床研究
出版日期:
2020-12-15

文章信息/Info

Title:
Correlation between serum miR-122 level and prognosis of patients with acute-on-chronic hepatitis B liver failure
文章编号:
1002-2600(2020)06-0022-04
作者:
林 勇 林 春 孙 芳 周 锐 杨文彦 周丽娜叶雅妹 潘 晨
福建医科大学孟超肝胆医院肝病内科(福州 350025)
Author(s):
LIN Yong;  LIN Chun;  SUN Fang; ZHOU Rui;  YANG Wenyan;  ZHOU Lina; YE Yamei;  PAN Chen.
Department of Hepatology Internal Medicine, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian 350025,China
关键词:
血清miR-122;  乙型肝炎慢加急性肝衰竭;  预后
Keywords:
serum miRNA-122;  acute-on-chronic hepatitis B liver failure;  prognosis
分类号:
R575.3
文献标志码:
B
摘要:
目的 探讨乙型肝炎慢加急性肝衰竭患者血清miR-122与疾病预后的相关性。方法 入组乙型肝炎慢加急性肝衰竭患者52例,收集患者临床资料、血液生化、乙肝病毒学指标、凝血功能指标、血清miR-122水平,计算终末期肝病模型(MELD)评分,记录随访3个月后患者的生存状态。采用Spearman相关分析血清miR-122水平与乙型肝炎慢加急性肝衰竭患者预后的关系,并采用非条件logistic回归进行多因素分析。结果 血清miR-122水平与乙型肝炎慢加急性肝衰竭的预后呈负相关(r=-0.384,P=0.005)。乙型肝炎慢加急性肝衰竭患者血清miR-122表达与凝血酶原活动度(PTA)(P=0.053)、Cr(P=0.050)、预后(P=0.030)、MELD(P=0.080)具有相关性。结论 在乙型肝炎慢加急性肝衰竭患者中,血清miR-122水平与疾病预后呈负相关,高水平的血清miR-122可能预示预后较好,血清miR-122可能是乙型肝炎慢加急性肝衰竭患者判断预后一个潜在指标。
Abstract:
Objective To explore the correlation between serum miR-122 and prognosis of patients with acute-on-chronic hepatitis B liver failure.Methods A total of 52 patients with acute-on-chronic hepatitis B liver failure were enrolled.The clinical data, blood biochemistry, hepatitis B virological index coagulation function index and serum miR-122 level were collected.Followed up and recorded survival status after 3 months,serum miR-122 levels and survival status were analyzed by using Spearman correlation,and nonconditional logistic regression was used for multivariate analysis.Results The results showed that serum miR-122 levels were negatively correlated with the prognosis in patients with acute-on-chronic hepatitis B liver failure(r=-0.384,P=0.005).The expression of serum miR-122 was correlated with PTA(P=0.053), Cr(P=0.050), prognosis(P=0.030)and MELD(P=0.080).Conclusion In patients with acute-on-chronic hepatitis B liver failure, serum miR-122 level is inversely correlated with disease outcome, and high level of serum miR-122 may predict a good prognosis.

参考文献/References:

[1] Jalan R, Gines P, Olson J C, et al.Acute-on chronic liver failure[J].J Hepatol, 2012,57(6):1336-1348.
[2] Mitchell P S, Parkin R K, Kroh E M, et al.Circulating microRNAs as stable blood-based markers for cancer detection[J].Proc Natl Acad Sci USA, 2008,105(30):10513-10518.
[3] Elfimova N, Schlattjan M, Sowa J P, et al.Circulating microRNAs: promising candidates serving as novel biomarkers of acute hepatitis[J].Front Physiol, 2012,3:476.
[4] Jopling C.Liver-specific microRNA-122: Biogenesis and func-tion[J].RNA Biol, 2012,9(2):137-142.
[5] Nakamura M, Kanda T, Sasaki R, et al.MicroRNA-122 inhibits the production of inflammatory cytokines by targeting the PKR activator PACT in human hepatic stellate cells[J].PLoS One, 2015,10(12):e0144295.
[6] Fathi-Kazerooni M, Kazemnejad S, Khanjani S, et al.Down-regulation of miR-122 after transplantation of mesenchymal stem cells in acute liver failure in mice model[J].Biologicals, 2019,58:64-72.
[7] Kamath P S, Wiesner R H, Malinchoc M, et al.A model to predict survival in patients with end-stage liver disease[J].Hepatology, 2001,33(2):464-470.
[8] 中华医学会感染病学分会肝衰竭与人工肝学组, 中华医学会肝病学分会重型肝病与人工肝学组.肝衰竭诊治指南(2018年版)[J].中华肝脏病杂志,2019,27(1):18-26.
[9] Roderburg C, Benz F, Vargas C D, et al.Elevated miR-122 serum levels are an independent marker of liver injury in inflammatory diseases[J].Liver Int, 2015,35(4):1172-1184.
[10] John K, Hadem J, Krech T, et al.MicroRNAs play a role in spontaneous recovery from acute liver failure[J].Hepato-logy, 2014,60(4):1346-1355.
[11] Wang W J, Lai R T, Lu J, et al.Correlation between circulating miR-122 and prognosis of chronic HBV-related liver failure[J].J Dig Dis, 2016,17(5):334-339.
[12] 王柳毅,崔丽娜,冯义朝.肝脏特异性基因miR-122与肝脏疾病研究进展[J].中华消化病与影像杂志:电子版,2013,3(4):42-45.

备注/Memo

备注/Memo:
基金项目:福州市科技计划项目社会发展项目(2018-S-103-4)
更新日期/Last Update: 1900-01-01