[1]吴永希 林懿祺 庄文锦 吴钦伟 李 振 曾昭楠 谢晓亮 魏世超.发作性睡病与阻塞性睡眠呼吸暂停相关分析[J].福建医药杂志,2020,42(05):11-15.
　WU Yongxi,LIN Yiqi,ZHUANG Wenjin,et al.Correlation analysis between narcolepsy and obstructive sleep apnea[J].FUJIAN MEDICAL JOURNAL,2020,42(05):11-15.
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发作性睡病与阻塞性睡眠呼吸暂停相关分析()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
42
期数:
2020年05期
页码:
11-15
栏目:
临床研究
出版日期:
2020-10-20

文章信息/Info

Title:
Correlation analysis between narcolepsy and obstructive sleep apnea
文章编号:
1002-2600(2020)05-0011-06
作者:
吴永希 林懿祺 庄文锦 吴钦伟 李 振 曾昭楠 谢晓亮 魏世超1
福建医科大学省立临床医学院 福建省立医院睡眠医学中心(福州 350001)
Author(s):
WU Yongxi;  LIN Yiqi;  ZHUANG Wenjin;  WU Qinwei;  LI Zhen;  ZENG Zhaonan; XIE Xiaoliang;  WEI Shichao
Department of Sleep Medicine Center, Fujian Provincial Hospital,Provincial Clinical Medical College of Fujian Medical University,Fuzhou,Fujian 350001, China
关键词:
发作性睡病;  阻塞性睡眠呼吸暂停;  多导睡眠监测
Keywords:
narcolepsy;  obstructive sleep apnea;  PSG
分类号:
R766
文献标志码:
B
摘要:
目的 探讨发作性睡病伴与不伴阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)患者的睡眠特点及相关危险因素。方法 纳入发作性睡病患者25例,对其进行多导睡眠监测(PSG)、日间多次小睡潜伏期试验(MSLT)以及爱泼沃斯嗜睡量表(ESS)评估,观察并分析发作性睡病伴OSA组(n=12)与不伴OSA组(n=13)的睡眠特点及危险因素。结果 发作性睡病伴OSA组ESS得分为(18.08±4.14)分,高于发作性睡病不伴OSA组的(12.69±6.66)分,差异有统计学意义(t=2.449,P=0.024); 发作性睡病伴OSA组N1期百分比为(28.65±12.50)%,高于发作性睡病不伴OSA组的(16.50±10.22)%,差异有统计学意义(t=2.670,P=0.014); 发作性睡病伴OSA组N3期百分比为(10.64±4.96)%,低于发作性睡病不伴OSA组的(17.75±8.83)%,差异有统计学意义(t=2.504,P=0.021); 发作性睡病伴OSA组睡眠期觉醒总次数为(196.17±83.69)次,多于发作性睡病不伴OSA组的(112.30±73.12)次,差异有统计学意义(t=2.674,P=0.014); 发作性睡病伴OSA组睡眠期觉醒指数为19.95(17.15,29.13))次/h,高于发作性睡病不伴OSA组的13.20(7.85,19.15))次/h,差异有统计学意义(Z=2.720,P=0.007)。多因素logistic回归分析发现,觉醒指数为发作性睡病伴OSA的危险因素,相对危险度(OR值)为1.179[95%CI(1.017～1.367),P=0.029]。结论 发作性睡病伴OSA的发生率较高,且夜间睡眠紊乱、日间嗜睡程度更严重,临床上应注意鉴别。
Abstract:
Objective To investigate the sleep characteristics and related risk factors of patients with obstructive sleep apnea(OSA)or without sleep disorder based on narcolepsy.Methods A total of 25 patients with narcolepsy were enrolled.PSG monitoring, multiple sleep latency test(MSLT)and Epworth sleepiness scale(ESS)were used to evaluate the sleep characteristics and risk factors of narcolepsy with OSA group(n=12)and without OSA group(n=13).Results ESS score was higher in narcolepsy patients with OSA than that in those without OSA narcolepsy,with OSA group(18.08±4.14)points vs the narcolepsy without OSA group(12.69 ±6.66)points(t=2.449, P=0.024).OSA increased N1 percentage [(28.65±12.50)% vs(16.50±10.22)%, t=2.670, P=0.014)], decreased N3 percentage [(10.64±4.96)% vs(17.75±8.83)%, t=2.504,P=0.021)], increased total number of awakening during sleep period [(196.17±83.69)vs(112.30±73.12); t=2.674, P=0.014], and increased awakening index [19.95(17.15, 29.13)times/hour vs 13.20(7.85, 19.15)times/hour; Z=2.720, P=0.007].Multivariate logistic regression analysis showed that the arousal index was a risk factor for episodic sleep disease with OSA, and the odd ratio(OR)was 1.179[95%CI(1.017-1.367),P=0.029].Conclusion The incidence of narcolepsy with OSA is high.Compared to narcolepsy patients without OSA, nocturnal sleep disorder and daytime sleepiness are more serious in narcolepsy patients with OSA, which should be clinically differentiated.

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备注/Memo

备注/Memo:
基金项目:福建医科大学启航基金(2019QH1174) 1 通信作者,Email:weisc0506@163.com
更新日期/Last Update: 2020-10-20