[1]王丽梅 林 授 何小兰 詹友知 王 明.核酸检测单反应性献血者归队情况分析[J].福建医药杂志,2019,41(04):12-16.
　WANG Limei,LIN Shou,HE Xiaolan,et al.Analysis for reentry of blood donors by single NAT reactive[J].FUJIAN MEDICAL JOURNAL,2019,41(04):12-16.
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核酸检测单反应性献血者归队情况分析()
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《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
41
期数:
2019年04期
页码:
12-16
栏目:
临床研究
出版日期:
2019-08-15

文章信息/Info

Title:
Analysis for reentry of blood donors by single NAT reactive
文章编号:
1002-2600(2019) 04-0012-05
作者:
王丽梅 林 授 何小兰 詹友知 王 明1
福建省血液中心(福州 350004)
Author(s):
WANG Limei; LIN Shou; HE Xiaolan;  ZHAN Youzhi; WANG Ming
Fujian Blood Center,Fuzhou,Fujian 350004,China
关键词:
献血者归队;  核酸检测;  核酸鉴别检测;  单反应性
Keywords:
reentry of blood donor;  nucleic acid test;  NAT identification test;  single reactive
分类号:
R446.62; R37; R193.3
文献标志码:
B
摘要:
目的 分析核酸检测(NAT)单反应性献血者的归队情况。方法 回溯2012-2017年我 中心无偿献血者血液NAT单反应性和鉴别情况,以我中心在2016-2017年归队的233名献血者为 研究对象,进行ALT速率法检测,HBV、HCV、HIV、梅毒螺旋体(TP)两种不同厂家ELISA试剂检 测,HBV、HCV、HIV单人份NAT检测。并对其中归队检测反应性的11名献血者进行追踪检测。 结果 2012-2017年491 159名无偿献血者,0.33%血液NAT检测单反应性,其中30%鉴别为HBV DNA。233名归队献血者中,24.5%(57/233)归队检测反应性,75.5%(176/233)归队检测非反应 性。233名归队献血者中,76名既往鉴别为HBV DNA,44.7%(34/76)归队检测非反应性; 157名 既往鉴别为不可鉴别,90.4%(142/157)归队检测非反应性。11名追踪试验献血者追踪检测结 果为反应性8名,非反应性3名。结论 核酸检测单反应性献血者归队有其必要性和现实意义; 血站应根据实际情况,建立适合的核酸检测单反应性献血者归队策略并不断完善。
Abstract:
Objective To analyze reentry of blood donors by single NAT reactive.Methods Single NAT reactive and identification of volunteer blood donors in Fujian Blood Center from 2012 to 2017 were looked back.A total of 233 blood donors returned to be tested again in 2016-2017.All the samples were tested with ALT rate, HBV,HCV, HIV and TP by ELISA reagents from two different manufacturers, and multiplex NAT(HBV, HCV and HIV single person NAT).Eleven NAT reactive donors were tracked and detected.Results From 2012 to 2017,491 159 volunteer blood donors were tested.0.33% of them were single NAT reactive,and 30% of them were discriminated as HBV DNA.From 2016 to 2017, 233 deferred donors were back to test again,the results were 24.5%(57/233)NAT reactive,75.5%(176/233)NAT non-reactive.Among the 233 blood donors,76 donors were previously discriminated as HBV DNA, 44.7%(34/76)tested again were NAT non-reactive, 157 blood donors were previously non-discriminated reactive,and 90.4%(142/157)tested again were NAT non-reactive. Eleven NAT reactive blood donors were tracked,among them eight cases were NAT reactive,and three cases were NAT non-reactive.Conclusion Reentry of NAT reactive blood donors is very necessary and meaningful.Blood stations should be based on actual conditions,to establish a suitable strategy for reentry of donors by single NAT reactive,and constantly improve.

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备注/Memo

备注/Memo:
1 通信作者,E-mail:office@fjxyzx.org
更新日期/Last Update: 2019-08-15