[1]王小云 章路军 叶羽翀.神经根型颈椎病神经根性疼痛与炎性因子相关性研究[J].福建医药杂志,2019,41(01):13-15.
　WANG Xiaoyun,ZHANG Lujun,YE Yuchong..Correlational research between inflammatory factors and nerve root pain of patients with cervical spondylotic radiculopathy[J].FUJIAN MEDICAL JOURNAL,2019,41(01):13-15.
点击复制

神经根型颈椎病神经根性疼痛与炎性因子相关性研究()
分享到：

《福建医药杂志》[ISSN:1002-2600/CN:35-1071/R]

卷:
41
期数:
2019年01期
页码:
13-15
栏目:
临床研究
出版日期:
2019-01-20

文章信息/Info

Title:
Correlational research between inflammatory factors and nerve root pain of patients with cervical spondylotic radiculopathy
文章编号:
1002-2600(2019)01-0013-03
作者:
王小云 章路军 叶羽翀
福建医科大学附属闽东医院康复科(福安 355000)
Author(s):
WANG Xiaoyun; ZHANG Lujun; YE Yuchong.
Department of Rehabilitation, the Affiliated Mindong Hospital, Fujian Medical University, Fuan,Fujian 355000,China
关键词:
神经根型颈椎病;  神经根性疼痛;  炎性因子;  相关性
Keywords:
cervical spondylotic radiculopathy;  nerve root pain;  inflammatory factors;  correlation
分类号:
R493
文献标志码:
B
摘要:
目的 研究神经根型颈椎病后炎性因子与神经根性疼痛的相关性,将神经根型颈椎病后出现的神经根性疼痛程度量化和数据化,指导临床用药剂量和治疗,更好地评判疗效。方法 收集2016年10月至2017年10月在我院住院治疗的符合纳入标准的神经根型颈椎病患者20例作为观察组,健康体检者20例作为对照组; 采用酶联免疫吸附法检测静脉血中炎性因子IL-1、IL-6、IL-18和TNF-α表达水平,采用VAS评分评价各组神经根性疼痛程度,采用相关性分析研究IL-1、IL-6、IL-18和TNF-α表达水平和VAS评分之间的相关性。结果 与对照组比较,观察组的IL-1、IL-6、IL-18和TNF-α表达水平均显著增高,差异有统计学意义(P<0.05); VAS评分显著增高,差异有统计学意义(P<0.05)。神经根型颈椎病发生后炎性因子IL-1、IL-6、IL-18和TNF-α表达水平与神经根性疼痛呈正相关。结论 神经根型颈椎病患者静脉血中炎性因子IL-1、IL-6、IL-18和TNF-α表达水平较正常人高,与神经根性疼痛之间存在正相关关系,可作为指标反映神经根性疼痛程度,将神经根性疼痛量化和数据化,有利于指导临床用药剂量和治疗,更好地评判疗效。
Abstract:
Objective To study the correlation between inflammatory factors and nerve root pain of the patients with cervical spondylotic radiculopathy,to make the degree of the pain quantitative, guide the dosage of clinical medication and treatment, and to judge the curative effect better.Methods From October 2016 to October 2017,20 hospital patients with cervical spondylotic radiculopathy were chosen as the observation group and 20 normal persons as control group. ELISA was used to detect the expression level of IL-1, IL-6, IL-18 and TNF-α. Visual analogue scale was used to evaluate the degree of nerve root pain. Correlation analysis was used to analyze the correlation between IL-1, IL-6, IL-18, TNF-α and nerve root pain. Results Compared with the control group, the expression levels of IL-1, IL-6, IL-18 and TNF-α in the observation group were significantly higher than those in the observation group with statistical significance(P<0.01). Compared with the control group, the VAS score of the observation group was higher with statistical significance(P<0.01). The expression level of IL-1, IL-6, IL-18, and TNF-α was positively correlated with nerve root pain after cervical spondylosis of nerve root type. Conclusion The expression levels of IL-1, IL-6, IL-18, and TNF-α in the patients with cervical spondylotic radiculopathy are higher than those in normal person. The expression levels of IL-1, IL-6, IL-18, and TNF-α are positively correlated with nerve root pain after cervical spondylotic radiculopathy, which are the indexes to reflect degree of nerve root pain and make the pain quantitative to guide the dosage of clinical medication and treatment, and to judge the curative effect better.

参考文献/References:

[1] 谢艺燕, 赵学田. 中医治疗神经根型颈椎病临床研究进展[J]. 辽宁中医药大学学报, 2015(3):194-196.
[2] 张苓. 中医综合疗法治疗神经根型颈椎病的临床研究 [D].南京:南京中医药大学, 2015.
[3] Andrade P, Hoogland G, Garcia M A, et al. Elevated IL-1β and IL-6 levels in lumbar herniated discs in patients with sciatic pain[J]. European Spine Journal, 2013, 22(4):714-720.
[4] Huec J C L, Faundez A, Dominguez D, et al. Evidence showing the relationship between sagittal balance and clinical outcomes in surgical treatment of degenerative spinal diseases: a literature review[J]. International Orthopaedics, 2015, 39(1):87-95.
[5] 国家中医药管理局. 中医病证诊断疗效标准 [M].南京:南京大学出版社, 1994:21-22.
[6] 张延龄, 吴肇汉. 实用外科学[M].第3版. 北京:人民卫生出版社, 2012:1321-1326.
[7] 韩济生, 倪家骧, 中华医学会. 临床诊疗指南:疼痛学分册 [M]. 北京:人民卫生出版社, 2007:356-358.
[8] Peng Q L, Shu X M, Tian X L, et al. Expression of tumor necrosis factor-like weak inducer of apoptosis and fibroblast growth factor-inducible 14 in patients with polymyositis and dermatomyositis[J]. Arthritis Research & Therapy, 2014, 16(1):R26-R26.
[9] Butler P D, Mellecker C J, Rudert M J, et al. Single-bundle versus double-bundle Acl reconstructions in isolation and in conjunction with extra-articular iliotibial band tenodesis[J]. Iowa Orthopaedic Journal, 2013, 33:97.
[10] Kanamoto T, Tanaka Y, Yonetani Y, et al. Anterior knee symptoms after double-bundle ACL reconstruction with hamstring tendon autografts: an ultrasonographic and power Doppler investigation[J]. Knee Surgery Sports Traumatology Arthroscopy, 2015, 23(11):3324-3329.
[11] Manchikanti L, Hirsch J A. In Response to risks and pitfalls of epidural injections during management of lumbar disc herniation: few comments[J]. Korean J Pain, 2015, 28(3):219-220.
[12] Aras A B, Guven M, Balak N, et al. Evaluation of the association between matrix metalloproteinase 11 and intervertebral disc disease[J]. Turkish Neurosurgery, 2015, 26(2):274-279.
[13] Schäfer S, Berger J V, Deumens R, et al. Influence of intrathecal delivery of bone marrow-derived mesenchymal stem cells on spinal inflammation and pain hypersensitivity in a rat model of peripheral nerve injury[J]. J Neuroinflammation, 2014, 11(1):157.
[14] Da S T, Mills K, Brown B T, et al. Risk of recurrence of low back pain: a systematic review[J]. Journal of Orthopaedic & Sports Physical Therapy, 2017, 47(5):1.
[15] Eidson L N, Inoue K, Young L J, et al. Toll-like receptor 4 mediates morphine-induced neuroinflammation and tolerance via soluble tumor necrosis factor signaling[J]. Neuropsychopharmacology, 2017, 42(3):661-670.
[16] Iannitti R G, Napolioni V, Oikonomou V, et al. IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis[J]. Nature Communications, 2016, 7:10791.
[17] Mcneela E A, Burke A, Neill D R, et al. Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4[J]. Plos Pathogens, 2010, 6(11):e1001191.
[18] Barlan A U, Griffin T M, Mcguire K A, et al. Adenovirus membrane penetration activates the NLRP3 inflammasome[J]. Journal of Virology, 2011, 85(1):146.
[19] Sebo P, Osicka R, Masin J. Adenylate cyclase toxin-hemolysin relevance for pertussis vaccines[J]. Expert Review of Vaccines, 2014, 13(10):1215-1227.

更新日期/Last Update: 2019-01-20